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Neuromuscular junction: transmission and disorders

Disorders of disturbed neuromuscular transmission include the autoimmune disorder Myasthenia Gravis (MG), in which antibodies attack the receptors of the neuromuscular synapse. The symptoms manifest as fatiguable weakness of skeletal muscles in the face, in the neck, arms and legs and often cause droopy eyelids, difficulty swallowing and chewing etc. In many patients, there is also a subsequent muscle wasting, in particular in patients who have antibodies against the receptor muscle specific tyrosine kinase (MuSK). Our main research interest is to elucidate the pathogenesis of MG, improve diagnostics of disturbed neuromuscular transmission and to find new therepeutic interventions against the muscle wasting following chronic neuromuscular disorders. Additionally we aim at finding prognostic factors and unidentified pathogenic factors in autoimmune neuromuscular disorders where no antibodies have been characterized.




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